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KMID : 0370220220660040184
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Yakhak Hoeji
2022 Volume.66 No. 4 p.184 ~ p.191
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Intestinal Delivery Techniques for Live Microorganisms: A Brief Overview
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Kim Ji-Hyun
Hlaing Shwe Phyu
Lee Ju-Ho
Saparbayeva Aruzhan
Yoo Jin-Wook
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Abstract
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The gut microbiome is a critical determinant of human health and disease status. Administration of livemicroorganisms has emerged as an effective way to recover damaged gut microbiome for improving host health. However,live microorganisms are susceptible to various environmental stresses, including acidic pH during the gastric transit. Thus,appropriate delivery techniques are required to protect the live microorganisms during their transit to the target area andensure their release at a desired location such as ileum or ascending colon. In this review, we provide an overview ofintestinal delivery techniques for live microorganisms.
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KEYWORD
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Live microorganisms, Probiotics, Live biotherapeutic products, Gastric survival, Intestinal delivery
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